In a group of eighteen patients with glaucoma, the severity of ocular symptoms and the level of intraocular tension were found to correlate with emotions of anger, anxiety, or depression, and rarely with feelings of joy. Periods of tranquility were associated with remissions of signs and symptoms. In several of the cases excessive weeping either preceded the development of the glaucoma or alternated with elevations in intraocular pressure. It seemed, therefore, that emotional tension which did not find satisfactory release was an important factor in the exacerbation of the glaucoma. Ripley and Wolff suggest that in some individuals there is a concomitant participation of the aqueous humor regulation of the eye in emotional upheavals, and that the increase in intraocular pressure represents an inappropriate biological pattern of mobilization.