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The authors attempt to compare the effect of ACTH on the adrenal cortex function of psychotic and nonpsychotic patients. It seems that psychotic patients respond with greater than normal changes in carbohydrate metabolism after the injection of ACTH than do normals. Otherwise, the eosinophile count, uric acid and sweat sodium concentration were not significantly different. In
addition, the authors injected large amounts of ACTH into two manic depressive psychotics. No improvement was noted.