Following up recent work in which lysergic acid diethylamide (LSD-25) was used on psychotic patients, Forrer and Goldner administered the drug to six schizophrenic patients in order to clarify its physiological and psychic effects. This drug is a partial synthetic representative of the ergobasine group of the ergot alkaloids. It was administered by mouth in ascending doses, from 0.5 to 6 micrograms per kilogram of body weight. The results produced were slight increase in blood pressure and pulse rate, increased salivation and lacrimation, marked pupillary dilatation, increase in deep reflexes and slight ataxia. Psychically, it produced episodes of euphoria, increased amiability and accessibility, and increased spontaneous productivity. Also, however, hallucinations,