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Glaser and Hoch, in an attempt to evaluate the relationship between adrenocortical activity and the psychological state, administered large doses of corticotrophin to six schizophrenic patients, three men and three women. The dosage given was one hundred to two hundred mgs. daily for from ten to thirty days. None showed beneficial results. Five developed diffuse slow activity in the electroencephalogram. One showed an intensification of the psychotic reaction, similar to that seen in recent cases of psychotic reactions induced by corticotrophin or cortisone.