A brief clinical description is given of a patient who developed euphoria and severe apprehension following cortisone therapy administered because of an eye disease (myopic degeneration of both retinae, bilateral surgical aphakia). The euphoria is understood as a pharmacodynamic response to cortisone while the apprehension is analyzed as the fear of drug addiction. Thus, Hollender feels it is possible that 'cortisone addiction may be a serious problem in emotionally predisposed people'.