Hoagland and his colleagues compared adrenocortical physiology in normal and schizophrenic men by studying two groups, one of seventy-two normal men and one of sixty-seven schizophrenic men patients in the Worcester State Hospital. Each group was divided into a younger (age twenty to thirty-nine) and an older (age forty to sixty) group and various indices of adrenocortical function were tested. The reactions were studied at rest, after subjection to three stress tests, and after injection of corticotropin.