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Since elevation of mood is a side effect in patients with tuberculosis treated with isoniazid, Salzer and Lurie studied the effect of this drug on a group of psychiatric patients. It has previously been used on schizophrenic patients but not in treatment of anxiety states and psychoneurotic and manic-depressive depressions. Forty-one patients were studied, most of them of a depressive type and only one with a pure state of anxiety. The drug was given in most cases orally but in one case was given parenterally when the patient failed to respond to the oral medication. The dose was at first 50 mgm. three times a