Vascular changes in the skin in nineteen patients with a variety of diseases were observed in conjunction with experimentally induced emotional disturbances. Constriction of the arterioles and increased tone of the minute vessels were associated with expression of hostility. Such changes invariably accompanied attacks of

Raynaud's disease in the four cases studied. Similar changes in the skin vessels were noted in those experimental situations where anxiety was demonstrated. When depression was produced, the vascular changes consisted of arteriolar constriction but a decrease in tone of the minute vessels.