Of twenty-three patients with ulcerative colitis, twenty suffered from headaches. Ten of the twenty had migraine and the remainder showed a mixture of muscle-tension and conversion-hysterical types of headache. Times of occurrence of headache differed from times of active colitis. Of fifty-six episodes of headache studied, forty-six occurred when the patients felt in control, had taken an active stand, made a decision, or thought something through. There was opportunity to study forty-three episodes of bleeding, and all occurred when the patient was feeling, to varying degrees, helpless, hopeless, or despairing. Patients were unequivocal in differentiating the headache and bleeding. Loss of object and psychic helplessness are associated with bleeding colitis, whereas retention of object and relatively good control by the ego are associated with headache and constipation.