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Study of two thousand nine hundred twenty-four persons shows that illnesses appear in clusters; periods of good health alternate with periods of illness. Physical hardship, change of climate, toxic or infectious agents are of little significance. It is only occasionally that an infectious agent is by itself responsible for an illness. Effects of the life situation are the most important factors producing illness. Physical illness is most commonly related to emotional stress. What is innocuous to one person may be noxious to another.