In a previous article, the author presented studies of thirty-two women who developed lymphoma or leukemia following loss and threat of loss of important objects. In this article, he reports that in thirty-three children suffering from leukemia, the prodromal circumstances included the loss of their status as a vicarious object for the mother. The mothers developed psychological depressive manifestations and the children developed leukemia. Greene postulates that the disruption in this mother-child relationship leads to the manifest somatic illness based on the biological determinants predisposing to leukemia.