The title of this article refers to the use of the metaphors of immunology in describing the deliberate verbalization of countertransference feelings to the severely narcissistic patient in analysis. Freud's pessimistic views about the treatment of such patients are related to his unwillingness to verbalize his own negative feelings to the patient. The author is aware of the danger of contamination of the analysis by an incorrect statement but states it is useful for the analyst to express those negative feelings that have been induced in him by the patient. Four cases are described in which the analyst expressed his anger to the patient with beneficial results. The fourth case, supervised by the author, was one in which the patient, in effect, was given permission to commit suicide, albeit in the form of a question, and the student analyst was able to work this