Fifty people, seen at a child guidance center in childhood or adolescence, were later hospitalized with a diagnosis of schizophrenia. The authors relate twelve significant factors to chronicity: 1, psychotic or schizoid pathology in the mothering person; 2, no separation of any kind from the pathogenic families; 3, pre-illness history of poor social and sexual adjustment; 4, failure to continue in treatment, during childhood, for at least three months; 5, less acting out in the community; 6, no disorientation or confusion on admission; 7, no symptoms of depressive psychosis; 8, premorbid schizoid personality; 9, no clear precipitating events; 10, no concern with dying during the acute phase of the illness; 11, length of onset over six months; 12, schizophrenic reaction in the patient's heredity. Factors 1, 2, 4, and 5 may be new to the literature on prognosis.