In the course of twenty-five years one woman presented different types of depression: reactive depression, periodic depression, and agitated depression during menopause. She was treated at various time with E.C.T., psychoanalysis, psychotherapy, drugs, and a combination of the latter two. She responded favorably to each modality of treatment. A brief review of the theories of the causes of depression and of its medical treatment is presented, followed by a detailed case report. The author's thesis is that all depressions are overdetermined psychosomatic diseases with both psychic and organic causes; and that different varieties of depression necessitating different therapeutic approaches may occur in a single patient under different conditions.