Affective reciprocity between an infant and her caregiver is the matrix in which the infant develops physically, emotionally, socially, and cognitively. The case study of a sighted infant of two blind parents highlights the complexity of the infant-adult interaction. It brings out the fact that the human infant shows great adaptability to communication in the absence of a communicative channel as important as the parents' eyes. The development of a mutually satisfying infant-parent relationship is thus not tied to a particular sensory modality in a fixed manner, but is based on the success of establishing emotional reciprocity.