Earle describes her experience with patients undergoing limb amputations at a bone cancer center. These children are confronted with interrelated problems in at least four areas: (1) the effects of being in the hospital and being subjected to examinations; (2) the anticipation and the actuality of amputation; (3) the effects of long-term chemotherapy; and (4) the anticipation and, in some cases, the reality of death. There is a considerable variety of reactions, defenses, and coping mechanisms. Emphasis is placed on the need for helping hospital staff with their problems as well as help for the child and parents.