On five maps of cinema halls, 264 right-handed, 246 mixed-handed, and 360 left-handed students were requested to indicate which area they would choose to sit in. All three groups showed a preference for the right and a corresponding directional bias toward the left space. However, they differed significantly from each other on the magnitude of this bias, which was most pronounced in the right-handed students and less so in the left handers. It is assumed that lateralized mechanisms underlying such biases have developed evolutionarily and serve right-handed persons best. Nondextrality considerably reduces phenotypic expressions, but even left-handedness does not reverse the directional bias toward the left. It is also hypothesized that right, mixed, and left handers differ in a large number of behavioral choices and strategies, modeled by cerebrally lateralized mechanisms, and that cinema seating preference is only one such aspect.