Current scientific interest in how the mind works creates a major challenge for psychoanalysis. The author proposes metapsychology as a bridging concept for an interdisciplinary dialogue. She presents a new framework on a microstructural level, within which different psychic representations are hierarchically organized. This framework permits a detailed comparison with Alexander Luria's (1973) neuropsychological model of the working brain (including recent theories of affect), and makes it possible to delineate the similarities as well as the differences between the psychoanalytic model of the mind and the neuropsychological model of the brain.