“Irene is a name for a city in the distance, and if you approach, it changes” (p. 99). Thus does Italo Calvino (1974) muse on the question of desire, not necessarily desire in the sense of sensual gratification but desire for the “known” object—the end-quest of learning, the mastery of what was once hidden. Just so does this collection of essays attempt to explore new routes in the psychoanalytic journey, using as a guide the work and thought of Donald Winnicott. The city of thought that Winnicott stumbled on, and likewise built, is approached with varying degrees of accuracy.