Two central questions raised by Spezzano's commentary have to do with the extent to which we seek objectivity in psychoanalytic theory and practice, and the extent to which one or another set of methods (e.g., clinical observation) is adequate or optimal for generating that knowledge. A discipline and treatment devoted to understanding subjectivity is nevertheless devoted to objective knowledge about a patient's subjectivity, defenses, and so forth and requires valid theories to guide exploration, inference, and intervention. Seeking objective knowledge does not require a naïve empiricism ignorant of the limits of objectivity. We would do well to use multiple methods to learn about how the mind works and what leads to therapeutic change.