The phenomena of hysteria are first considered from a historical perspective that emphasizes the role of domination and power relations between the sexes. This permits an examination of the dynamics and impact of humiliation in interpersonal relations on the formation of hysteric symptomatology. Humiliation is viewed as having a powerful deleterious effect on the development of the capacity to think and feel in a coherent and meaningful manner. The relationship between humiliation and hysteria is explored theoretically and illustrated with clinical material that emphasizes developmental dynamics through which relationally based injuries fracture the ability to know and communicate one's experience.