In this paper I examine the phenomenon of “uncanny” unconscious communication and the plausibility of “telepathic” interconnectivity between patient and therapist. While reexamining long-standing psychoanalytic reluctance to engage with the topic of the “uncanny,” I present clinical examples of seeming anomalous transmission, followed by discussion from contrasting perspectives of psychoanalysis, neuroscience, quantum physics, and parapsychology. The patient’s and analyst’s reactions to these uncanny moments are explored, along with the potential clinical value of nurturing receptivity to this “frequency” of unconscious attunement.