The authors introduce this Special Issue of Psychodynamic Psychiatry focused on developments in the practice of Transference-Focused Psychotherapy (TFP). In the context of an evolving diagnostic system that increasingly focuses on the underlying dimensions related to self and interpersonal functioning that characterize personality disorders, the authors provide an overview of the development and nature of TFP, and preview a series of contributions that describe the refinement of TFP and is broadening application across the spectrum of personality disorder, age ranges, and clinical settings.