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Giuseppe Civitarese discusses the influence of Descartes’ method of radical doubt on Bion’s approach to psychoanalytic inquiry and its links with Bion’s concept of caesura. He argues that Bion’s work seeks to bring about a change in psychoanalytic method, from a technique of decoding to a means of enhancing the patient’s capacity to dream reality, and he stresses the importance of attunement with the patient to enable psychic growth. He links the shift in Bion’s way of thinking about the aims and methods of analysis to his shift to a more aesthetic mode of presentation of his ideas.