In this article we consider Nobel Prize Winner Gerald Edelman’s remarkable contribution to the understanding of human evolution, and our own application of Edelman’s theory to a brain-based psychoanalytic perspective we have devised. Edelman’s paradigm setting out his theory of the evolution of mind, brain, and consciousness concerns not only mankind’s evolution over all of time, but also the evolution of each and every individual over and within his single lifetime. Edelman contends that human beings, as individuals, and not only as the taxonomic category from which they sprang, have a separate and distinct evolutionary history of their own, and it is especially from within Edelman’s theoretical assumptions about the evolution of the individual per se that our own psychoanalytic understanding of theory and practice derives.