This article contends that psychoanalysis benefits from a neurobiological perspective. It is suggested that Antonio Damasio’s view on the neurobiology of mind and self is particularly useful in this regard. The article presents a review and discussion of Damasio’s basic assumptions on body, emotion, feeling, unconscious and conscious mind, and embodied self. It explains how Freud’s hypotheses that ego is first and foremost a bodily ego is underpinned by contemporary neurobiological research and theory. A clinical illustration highlights that changes in sense of self encompasses changes throughout the whole body, as felt from the inside and as observed from the outside.