Clinical vignettes along with applicable neuroscientific research findings are considered for the purpose of examining the utility of neuropsychoanalysis to psychoanalytic thought and practice. Several fundamental psychoanalytic concepts are revisited along both lines. Among them are: identification, embodiment, attachment, drive, danger situations, dreams, memory, metaphor, conflict, defense. In the process, the metapsychology of the “mental apparatus” gains renewed attention. The article uses instances of three different clinical situations as moments open to neuro-psychoanalytic explorations of several basic psychoanalytic propositions: on the couch; on the phone; in the chair.