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The enduring legacy of trauma from slavery’s effects is remembered in the body. This remembering affects the mental and physiological health of the descendants of enslaved African Americans to this day. Slavery, characterized by extreme violence, deprivation, and dehumanization, inflicted profound psychological and physical trauma on millions of African Americans. Its abolition did not mark the end of racial oppression; rather, subsequent generations have faced systemic racism, segregation, and discriminatory practices that perpetuate economic, social, and psychological disadvantages. The cumulative impact of these experiences has been transmitted across generations causing foundational alterations in bodily processes, with significant clinical sequelae. Epigenetic research indicates that trauma can alter gene expression in ways that may predispose descendants to mental health issues such as depression, anxiety, and post-traumatic stress disorder (PTSD). This article explores factors associated with the collective interpsychic memory of the descendants of enslaved.