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In discussing Sirote’s compelling, intimately candid, thoughtful, and provocative paper, I focus on three issues: the centrality of negotiation in therapeutic process, the clinical impact of affirmation versus mystification when the intersubjective field is saturated with negative affect, and a set of questions that seek to contextualize Sirote’s notion of expanding the frame. I consider as well the larger existential frame within which the therapeutic frame is negotiated and lived within the heartbeats of a human relationship.