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Work with children on the autistic spectrum and their families is described and illustrated from a mentalization-based therapy lens. Focus on the importance of working with parents from a therapeutic stance that models an interactive style and on the capacity to “find and be with” a child on the autistic spectrum is described. The MBT intervention seeks to offer an alternative model of relationship which fits both the child’s “regulation profile” and his caregiver’s capacity to learn and generalize a new way of connecting and communicating. These aims are achieved through the application of a scaffolding approach, one that seeks to provide a developmental experience within a secure and predictable, yet flexible, therapeutic framework with the central aim of improving psycho-social functioning and increased emotional regulation skills for this population.