The relation between self-reported frequency of nightmares, as well as a number of saliency measures of the nightmare experience, and a self-report measure of annihilation anxiety was evaluated in two, independent college student populations. A significant positive relation was found between nightmare frequency and salience and annihilation anxiety. Furthermore, these findings were cross-validated across both samples. The results are discussed within the context of object relations and ego psychology theory utilizing an ego boundary model and are consistent with previous research demonstrating boundary impairment in self-reported frequent nightmare subjects.