This article is an attempt to explore the impact of science and technology on the nature of experience and sense of self, with a focus on changing conceptions of the body, sexuality, and privacy. Although Freud and early psychoanalysts were pivotal in the application of science to private life and bringing sexuality to a public forum, the shift to a relational emphasis within the field, particularly in America, paved the way for the ascendance of the more technologically oriented sex therapy. The author suggests that the technological innovations of the cyberage have altered fundamental processes of perception and experience, conflating private and public, and changing subjective sense of self, the body, sexuality, and reality, posing new theoretical and clinical challenges for psychoanalysis.