The author presents a dynamic systems approach to psychoanalytic practice. It depicts psychoanalysis as an activity-dependent, experientially based treatment in which the analyst's behavior toward a patient effects change in how the patient organizes and interprets self-experience and relates to others. The neurobiological and relational components of this approach are reviewed, and their implications for psychoanalytic process and technique are described. Several clinical vignettes illustrate the technical application, dynamic process, and therapeutic action of a dynamic systems perspective on psychoanalytic treatment.