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Scientific advances and cultural change are occurring at such a pace that it is difficult to make any meaningful predictions about what the world will look like over the next 100 years. Freud's discoveries will hopefully live on and become integrated into a general psychology of the human mind. Transference, a developmental viewpoint, a dynamic unconscious, valence to all mental life, and finally conflict and defense as a part of all mentation are the core components which will likely be preserved. Demands for empirical verification of psychological constructs and treatment will continue, and analysts must become more active in helping to formulate the research so that analytic knowledge can be fairly tested, proven, and disproven. Interdisciplinary cooperation both in research and education is a key element in psychoanalysis' survival, especially in the area of neurobiology. Numerous examples of this collaboration are presented. Finally, there are 2 types of errors in interdisciplinary collaboration which are to be avoided: (1) reductionism, or (2) the faddish, analogical, or metaphorical of importation of concepts from one discipline into the other.