The potential and current impact of the COVID-19 pandemic on the socioemotional functioning of children, adolescents, and their families are explored through research evidence and a developmental-psychoanalytic perspective. We depart from the pioneering efforts and lessons learned from Anna Freud's Hampstead War Nurseries about the value of clinical observation and its impact on technical modifications during moments of crisis. Furthermore, we illustrate and reflect on the benefits of the application of a mentalization-based lens during online clinical work with children, adolescents, and families. The need for technical modifications that adapt themselves to the sociocultural needs of the families we serve during moments of crisis is emphasized.