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This large committee was headed by Dr. George B. Wallace, was financed by three foundations, and worked four years. Among the conclusions reached by the committee are: Marihuana is used extensively in the Borough of Manhattan but its use is not widespread among school children. The publicity concerning the catastrophic effects of marihuana smoking is unfounded. The difference between marihuana smoking and taking marihuana extracts by mouth is that in smoking the effects come on promptly and are of much shorter duration. The sensations desired are pleasurable ones, a feeling of contentment, inner satisfaction and a free play of imagination. Once this stage is reached, the “experienced user” realizes that with further smoking the pleasurable sensations will be changed to unpleasant ones and so takes care to avoid this. The new feeling of self confidence induced by the drug expresses itself primarily through oral rather than through physical activity. Feelings of disinhibition and anxiety are also released but the basic personality structure does not appear to change. However, 9 out of 87 subjects studied clinically or 12 per cent of the subjects, had psychotic episodes. The typical effects of marihuana are ascribed to actions on the central nervous system.