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This report of the third Macy conference on the adrenal cortex, under the chairmanship of Professor C. N. Hugh-Long, is a comprehensive one and includes the following discussions: “The Effects of Adrenal Cortical Hormones on Renal Function”, led by Robert F. Pitts of Cornell University; “The Hypothalamus and Regulation of ACTH Secretion”, led by Geoffrey H. Harris of Cambridge; “Determination of Adrenal Cortical Steroids in Blood”, led by Don H. Nelson of the University of Utah; “The Biogenesis of Adrenal