In France, transsexualism was introduced in psychoanalysis through the mediation of medicine. The statements of psychoanalysts on transgender people are considered as offensive by the people concerned. Since the 1970s, trans* people have refused to be objectified as “clinical cases” and have decided to “zap” psychoanalysis, the vehicle for a violent, discriminatory rhetoric redolent of psychiatry. Is a critical debate between the knowledge derived from the Freudian field and from the gay, lesbian, and trans* field possible in order to revamp the questionings on gender and sexuality? Can psychoanalytical theory and practice overcome their political-psychiatric origins by taking into account the knowledge and theories of transpédégouines (“transgaylesbian” or “queer”)?