Though self psychologists frequently treat clients who also require pharmacotherapy, the contributions of self psychology to our understanding of the collaborative process have not been formally addressed in the literature. The author presents an in-depth clinical illustration of how two self psychologists successfully collaborated in treating a severely bipolar woman. The case also demonstrates the importance of integrating depth psychological analytic understanding with clinical social work practice, and highlights the crucial role of the empathic vantage point in facilitating effective collaboration.