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In his two part series on psychoanalysis and “homosexuality,” William Meyer lays out a sordid history of psychoanalysis wielded against gender and sexual minorities. The present article is an extension on that work into the realm of “transsexuality.” Analyzing the work of Freud, Rado, Bieber, Socarides, Ovesey, Stoller, and Money, the psychoanalysis of “transsexuality” demonstrates a parallel history to the psychoanalysis of “homosexuality.” From a critical departure from psychoanalytic inquiry as presented by these authors, transgender activists and theorists have presented a model of transgender subjectivities arising from the tradition of the feminist personal-political challenge to the divided private and public spheres. Pointing toward a transformation of psychoanalysis, transgender subjectivities recenter the somatic and political within the relationality of analyst and analysand. The article concludes a direction for psychoanalytic practice with transgender people thus maintains: (1) a personal-political paradigm of liberation practice, (2) an investment in somatic treatment, and (3) a relational practice establishing mutual personal-political struggle.