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Christine Jorgensen's widely publicized sex reassignment surgery in 1952 brought transsexualism to worldwide attention and fostered medical interest in transsexualism. Joanne Meyerowitz has traced the history of Jorgensen's personal odyssey, the medical history of transsexualism, and the broader impact of transsexualism on United States culture. In this interview, Meyerowitz discusses how she came to this project and some of its theoretical and methodological challenges. Finally, she sets her historical work in the context of contemporary gender and transgender politics.