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This article uses Bracha L. Ettinger’s theory of the matrixial borderspace in relation to Jacques Lacan’s analytic of sexuation to argue that transsexuality isn’t reducible to psychosis. Rather, transsexuality taps into an Other (feminine) sexual difference that is subjectifying and can be understood in relation to Ettinger’s conception of metramorphosis and the matrixial. Transsexuality involves the somatization of the Other sexual difference and the creative use of this difference as sinthome. The sinthome of transsexuality can enable the subject to negotiate the aporia of sexual difference. I establish parallels between the (neurotic) hysteric and the transsexual to argue that transsexuality can be a subset of neurosis. The transsexual transition (which often involves Sex Reassignment Surgery) can be understood as a metramorphical becoming, a borderlinking enabling separation and distance in proximity. It is not as Catherine Millot (1990) contends an attempt to abolish the “nature” of the Real but rather a means to achieve a sinthomatic reknotting of the 3 Registers such that one’s relation to a parental image and to an Other’s primordial traces can be reconfigured.