Critique of instantiated discourses and practices seems to have ushered in an interregnum, a pause wherein a crisis of meaning ensues. This pause provides an opportunity, a space for new forms of reflection and novel formulations about what it is to be human. This special issue introduces a collection of papers representing a rich tapestry of feminist, decolonial, psychoanalytic, queer, and clinical insights which pave inroads into making sense of and transforming possibilities for being and practicing. The papers in this issue coalesce around three dimensions and commitments: (1) recentering marginalized epistemology, (2) reconfiguring ontological assumptions, and (3) providing possibilities for being and practice beyond the foreclosures of hegemony. In so doing, the authors provide scholarly and clinically sophisticated resources for navigating cultural territory where conventional and mainstream meanings and methods are in significant flux. Each of the pieces in this special issue was presented in the “Gender and Sexuality” track at the Psychology and the Other Conference .