A study on the subjective experience of neuroleptic treatment is used as an example of research that employs psychoanalytic theory and methodology outside the clinical situation. Psychoanalytic tenets such as psychosexuality and the unconscious are highlighted, and the systematic study of internal reality is discussed with reference to the study on neuroleptics, the results of which are presented in extenso. Metapsychology is considered as a means for systematization, and self-reflexive countertransference analysis is seen as a means for fostering trustworthiness and reliability. The validity criteria discussed are clincal relevance, coherence, and originality (as distinct from merely confirming received theory). Value conflicts between academic and psychoanalytic scientific cultures are described with reference to the data of the specimen study. The concluding discussion includes a brief comparison of the time-limited interview method with long-term, clinical psychoanalytic inquiries.