In the preceding article, “How Do You Solve a Problem Like Agbon?: The Trials and Tribulations of Applying Diagnoses to Children of a Foreign Culture,” Dr. duPlessis describes the complex case of Agbon, a six-year-old African child who was referred for a cognitive-academic evaluation. Dr. duPlessis thoughtfully reflects on a number of important ethical and clinical considerations involved in evaluating and diagnosing a child with unique and challenging experiences. This article further explores the complex issues involved in the assessment and diagnosis of children from diverse cultures. Issues including acculturation stress, the appropriateness of using tests developed for Western cultures with children from diverse backgrounds, as well as the sensitivity of the DSM-5 to cultural influences are discussed.