Divergent views of the utility of neuroscience for organisation and management consultation range from idealised to sceptical to dismissive. This situation is in large part due to the absence of specific interventions being shown to improve consultant or client performance and analysis of how they work. Here a neuropsychoanalytic paradigm of Mind that comprises: (1) subjectivity; (2) consciousness/unconsciousness; (3) intentionality; and (4) agency is applied to leadership and executive coaching. Implementing this model in the context of emotions (instinctive feelings) and affects (experienced feelings) bridges neuroscience and psychology. Examples are offered of how this synthesis practically promotes leaders' ability to go beyond emotional intelligence and mindfulness to actually “knowing their minds” as a methodology to enhance executive and organisational functions at work.