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In this third year of the global Covid-19 pandemic, we are in touch with the tragedy of life, our fear of extinction, and the anxieties associated with the regression of human civilisation. Fatigue and exhaustion, coupled with existential burnout and profound sadness is apparent in all thirteen global reports. Covid has interrupted our sense of personal continuity and omnipotence, confronting us with our vulnerabilities and exigencies, fuelled by our failed economic, political, and social models. The weakening of shared values, fragmentation of relations, increasing aggression, and social chaos augment divisions and splitting. As we connect with inequality and privilege, some experience guilt and discomfort. Many are awakening to the interconnectedness of all things, and our individual and collective responsibilities. We need credible and reliable leadership to rebuild trust, and responsible, functioning political authorities and institutions to help foster belonging, protection, and agency. We are struggling to think enough, care enough, and act enough. “Let's wake up” to the available resources within us and externally, rediscovering positive energies and the courage to live with contradictions, engaging our “inoculated selves against seeing injustices” and acting responsibly towards our common home and the common good. Will we succeed?