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Sibling relationships are formative and uniquely positioned within early social networks, not as authoritative as the parent-child relationships nor as optional as friendships. Psychoanalysis has incorporated assessments of sibling dynamics into practice, even as sibling relationships have received little formal attention in the literature. This article applies insights from the study of neural and cognitive development to help inform how sibling relationships may be formed, and in doing so offers a fresh perspective into the enduring influence of our earliest familial bonds. Specifically, the author argues that beginning in infancy, the sibling dynamic is shaped by a complex interplay of developing memory systems, changing schemas, and familial influences.