Drawing on clinical vignettes, I present different facets of deep psychic suffering such as fear of extermination, catastrophic phobia, excessive guilt, moral degradation (unconscious introjection of the character of collaborator-whistleblower), traumas due to a domination of the reality principle over the pleasure principle, the annihilation of human respect and the syndrome of being a victim of the system. These aspects operate in the destiny of the patient as well as that of the analyst.