The Co-Editors-in-Chief of The Psychoanalytic Study of the Child introduce two clinical papers on Gender Dysphoria which include detailed clinical material from the analyses of four children born biologically female. They emphasize the importance of a psychoanalytic developmental theory as a foundation for analytic work with children and adolescents, and promote the idea of ongoing conversations in our field regarding these complicated issues. They encourage readers to reflect on the analytic material with a curious mind and an attitude of not knowing, to further their own insights into the complicated issue of gender and Gender Dysphoria and to contribute to the conversation.